Pathological analysis of lesions in the exocrine pancreas of rats induced by Zinc Maltol

The pancreas plays an important role in the homeostasis of zinc (Zn), a nutritionally essential metal. In several previous studies, Zn ions induced inflammatory changes exocrine pancreas; however, little is known about complexes. this study, we microscopically, immunohistochemically, and ultrastructurally examined pancreatic lesions Sprague-Dawley (SD) rats by 4-week repeated oral dose toxicity study Zinc Maltol (ZM), (II) complex. ZM induces acinar atrophy increases number duct-like structures. Immunohistochemistry revealed decrease trypsin-positive cells, increase SOX9-positive cells. Interstitial fibrosis macrophage infiltration also correlated with degree atrophy. Electron microscopic evaluation that cells lost granules were surrounded fibroblasts collagen fibers. conclusion, provided detailed description ZM-induced SD rats.